June 17, 2025

What Supplements Lower Cortisol? A Complete Guide to Natural Stress Relief

Struggling with stress and fatigue? Learn which science-backed supplements naturally lower cortisol, support adrenal health, and help your body find its calm—even when life won’t slow down.

What Supplements Lower Cortisol? A Complete Guide to Natural Stress Relief

Cortisol, often called the “stress hormone,” plays a key role in the body’s response to stress. While it helps regulate blood sugar, energy levels, and the immune system, prolonged high levels of cortisol can lead to negative health effects. 

Symptoms such as anxiety, fatigue, weight gain, and sleep disturbances are common indicators of elevated cortisol. Fortunately, there are natural ways to balance cortisol levels, including targeted supplements. 

These solutions can help support your adrenal glands and restore calmness. JM Drugstore is a trusted resource for pharmacist-approved supplements designed specifically for stress relief.

Why Does Cortisol Spike?

Cortisol is a hormone produced by the adrenal glands as part of the body’s natural stress response. When faced with stress, cortisol helps manage the immediate energy demands by increasing blood sugar and suppressing non-essential functions, like digestion.

However, chronic stress—from demanding jobs, poor sleep, or an unbalanced diet—can cause cortisol levels to remain elevated. This prolonged state of stress can negatively impact your overall well-being.

When Cortisol Stays Too High

When cortisol levels remain elevated, the effects can ripple through various aspects of your health, including:

  • Sleep: Difficulty falling or staying asleep at night

  • Immune Function: Increased vulnerability to illness and infections

  • Mood: Heightened anxiety, irritability, or depression

  • Metabolism: Weight gain, particularly around the abdomen

  • Hormonal Balance: Disruptions that may lead to fatigue or hormonal imbalances

Addressing high cortisol requires a combination of lifestyle changes and targeted supplementation.

Adaptogens to the Rescue: Nature’s Stress Soothers

Ashwagandha

Ashwagandha is a powerful adaptogen widely studied for its ability to lower cortisol. It helps reduce anxiety, improve sleep quality, and stabilize mood. 

JM Drugstore offers Ashwagandha 240, a pharmacist-recommended product designed to help your body adapt to both physical and mental stress while supporting restful sleep.

Rhodiola Rosea

Rhodiola Rosea is another adaptogen known for enhancing stress resistance. It can reduce fatigue and improve mental performance, making it an excellent choice for busy mornings. Its gentle energy boost avoids overstimulation, keeping you balanced throughout the day.

Holy Basil (Tulsi)

Holy Basil, also known as Tulsi, supports adrenal function while calming the mind. Commonly used in tea or capsule form, this versatile adaptogen is available at JM Drugstore, offering you convenient options for daily use.

Amino Acids and Nutrients That Tame the Stress Hormone

Phosphatidylserine

Phosphatidylserine, a brain-supportive nutrient, has been shown to lower cortisol levels following episodes of mental or physical stress. It’s particularly helpful for those experiencing burnout or struggling with brain fog.

L-Theanine

Found naturally in green tea, L-theanine helps promote calm focus by encouraging alpha brain wave activity. When combined with caffeine, it delivers alertness without the jitteriness.

Magnesium

This essential mineral is a key player in regulating the nervous system and cortisol release. Magnesium glycinate, known for being gentle on the stomach, is available at JM Drugstore to help ease both body and mind.

B Vitamins and Herbal Helpers for Hormone Harmony

B-Complex Vitamins

B-complex vitamins help support adrenal glands and combat fatigue caused by sustained stress. They’re especially beneficial for individuals juggling demanding schedules or dealing with emotional burnout.

Licorice Root (Deglycyrrhizinated)

Licorice root extends the half-life of cortisol, making it useful for managing adrenal fatigue. However, this supplement should only be used under the guidance of a healthcare professional to ensure safety and proper balance.

Sleep Support and Cortisol Control: The Overlooked Connection

Sleep is one of the most critical factors in cortisol regulation. When rest is disrupted, cortisol levels can remain elevated, setting off a vicious cycle.

Melatonin

Melatonin, a natural hormone, helps restore circadian rhythms and reduce nighttime cortisol spikes. It’s most effective when used short-term under professional advice.

GABA and Lemon Balm

GABA, an amino acid, promotes relaxation by calming an overactive mind. Similarly, lemon balm helps alleviate nervousness and restlessness, making it easier to achieve restorative sleep.

Your Calm Starts Here: Stress Support at JM Drugstore

At JM Drugstore, we understand the impact stress can have on your life. That’s why we offer a curated selection of pharmacist-approved supplements to support adrenal health and regulate cortisol levels.

One standout product is Cortisol Tuner, a multifunctional formula designed to promote mental clarity, alleviate occasional fatigue, support healthy cortisol levels, and encourage restful sleep.

If you’re unsure where to start, talk to our knowledgeable staff about your symptoms—we’ll help match you with the right solutions. Shop our full line of stress support supplements today and begin your calm recovery!

Conclusion: Say Goodbye to Stress Overload Naturally

High cortisol doesn’t have to be your “new normal.” By incorporating targeted supplements and following professional guidance, you can reclaim control over your mood, energy, and sleep.

JM Drugstore is here to support your stress recovery with pharmacist-recommended products tailored to your needs. Visit us today or contact our team to explore effective solutions for natural stress relief.