Only available to ship to Texas, Tennessee, Arkansas, and Idaho.
Ivermectin is a semisynthetic anthelminthic agent; it binds selectively and with strong affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to increased permeability of cell membranes to chloride ions then hyperpolarization of the nerve or muscle cell, and death of the parasite.
How to take: Administer on an empty stomach with water
Dosing for adults:
Classic scabies, treatment: Oral: 200 mcg/kg once; repeat dose in 7 to 14 days
Strongyloidiasis (Roundworm): Patients who are immunocompetent: Oral: 200 mcg/kg once daily for 1 or 2 days
Onchocerciasis (River Blindness): Oral: 150 mcg/kg once; repeat dose every 3 to 6 months until asymptomatic
1kg = 2.2lbs
Do not take if pregnant or breastfeeding. Please refer to a pediatrician for pediatric dosing.
Drug Interactions:
Vitamin K Antagonists (Warfarin): Ivermectin (Systemic) may increase anticoagulant effects of Vitamin K Antagonists
Common Adverse Effects:
- ≥10%: Miscellaneous: Mazzotti reaction (associated with onchocerciasis: pruritus: 28%; fever: 23%; skin edema, papular rash, pustular rash, and urticaria: ≤23%; arthralgia and synovitis: ≤9%; lymphadenitis [axillary node: 4% to 11%, cervical node: 1% to 5%, inguinal node: 13% to 14%, other lymph node: 2% to 3%]) 1% to 10%:
- Cardiovascular: Orthostatic hypotension (1%), peripheral edema (3%), tachycardia (4%)
- Dermatologic: Pruritus (associated with strongyloidiasis: 3%)
- Gastrointestinal: Diarrhea (2%), nausea (2%)
- Hematologic & oncologic: Decreased white blood cell count (3%), eosinophilia (3%), increased hemoglobin (1%)
- Hepatic: Increased serum alanine aminotransferase (2%), increased serum aspartate aminotransferase (2%)
- Hypersensitivity: Facial edema (1%)
- Nervous system: Dizziness (3%)
- Ophthalmic: Inflammation of limbus of eyes (4% to 6%), punctate cataract (1% to 2%)
Targets Parasite Nervous System
